Answer
The best way to combine these ideas is “Sedentary lifestyles are harmful and lead to disease.” This statement is clear and grammatically correct, effectively conveying that a sedentary lifestyle poses risks and may result in health issues. It emphasizes the harmful nature of such a lifestyle and the potential consequences, which include disease. Other options in the question, such as “Sedentary lifestyles are a result of harmful disease,” “Lifestyles that result in disease are harmful and sedentary,” and “Lifestyles that are sedentary are harmful and result in disease,” do not express the idea as directly or clearly.
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