Short Answer 
To measure 0.25 ml of liquid, hold the syringe upright and press the plunger down before inserting it into the liquid. Pull back the plunger slowly until the liquid reaches the 0.25 ml mark, double-check the measurement, and then remove the syringe carefully while adhering to safety protocols.
Step 1: Prepare the Syringe
Begin by holding the syringe upright with the needle pointing upwards. This position helps prevent any air bubbles from forming, which can affect your measurement. Ensure that the plunger is fully pushed down to the bottom of the syringe to allow for accurate filling of the liquid.
Step 2: Measure the Liquid
Carefully insert the tip of the syringe into the liquid you wish to measure. Slowly pull back on the plunger, allowing the liquid to flow into the syringe. Keep a close eye on the measurement scale, and stop pulling back just when the liquid reaches the 0.25 ml mark. If there is no exact marking, estimate by using the smaller increments.
Step 3: Confirm and Use the Measurement
After reaching the desired measurement, double-check that the liquid level is indeed at 0.25 ml for accuracy. Once confirmed, carefully remove the syringe from the liquid while ensuring not to lose any liquid. You can now use the measured liquid as needed, always remembering to handle syringes and needles with care and follow safety protocols.